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Established in 2007 by the friends and family of Christine Koski ’79 in honor of her 50th birthday, this fund supports students majoring in the sciences.

Testing the Efficacy of Cerium Oxide Nanoparticles against Oxidative Stress Fluorescence Marker in C. Elegans

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Characterized by a gradual disintegration of the neuronal network, neurodegeneration lies at the crossroads of numerous pathologies such as Parkinson’s, Alzheimer’s disorders, multiple sclerosis, stroke, and others. While the cause of neurodegeneration is often multifactorial in nature (e.g., genetic, age, environmental factors), oxidative damage tends to be a common denominator in the process.

  • Transgenic C. elegans, roundworm model organism, fluorescent reporter strains for the detection of oxidative stress in vivo under experimental conditions observed through a fluorescence microscope. Left: green fluorescent protein (GFP) attached to superoxide dismutase 3 enzyme (endogenous antioxidant), allowing for quantitative measurement of oxidative stress with fluorescence intensity; right: GFP attached to DAF-16 transcription factor for qualitative assessment of oxidative stress impact in C. elegans in