EBI2 as a potential target in Multiple Sclerosis (MS) therapy
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In the summer of 2025, I had the pleasure of spending the entire month of June at Rutkowska Lab, located at the Medical University of Gdańsk. The research facility, where I interned, focuses on experimental analysis of the offset and therapy of Multiple Sclerosis (MS). As a laboratory assistant, I was able to participate in the investigation of the Epstein-Barr virus-induced gene 2 (EBI2) in the context of therapy for MS. EBI2 is a promising target as it promotes remyelination and immunomodulation in the brain.
In the laboratory, I worked under a PhD student, Fatimah, who taught me many experimental techniques, as well as, showed me how to manage a laboratory space. Most of the procedures we practiced focused on tissue preparation, such as OPC isolation, astrocyte and microglia sourcing and growth, and dissection of cerebellar slices. Additionally, I had a chance to help with the routine lab maintenance, such as an incubator or fume hood cleans, or inventory inspection.
My internship deepened my understanding of the scientific method and showed me the reality of research, which is so often associated with repeated failure. Twice, our meticulously prepared cells got infected and died before getting the chance of being stained. Another time, the stain concentration used for cerebellar slices, which took 4 weeks to prepare, turned out too low, and the fluorescence was not strong enough. It gave me an appreciation for the research and constant search for improvement, as by the end of my internship, we had a greater idea of the direction in which we should move.
I hope to return to Rutkowska Lab in the future and further pursue my love of science.