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Testing the Efficacy of Cerium Oxide Nanoparticles against Oxidative Stress Fluorescence Marker in C. Elegans

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Characterized by a gradual disintegration of the neuronal network, neurodegeneration lies at the crossroads of numerous pathologies such as Parkinson’s, Alzheimer’s disorders, multiple sclerosis, stroke, and others. While the cause of neurodegeneration is often multifactorial in nature (e.g., genetic, age, environmental factors), oxidative damage tends to be a common denominator in the process.

  • Transgenic C. elegans, roundworm model organism, fluorescent reporter strains for the detection of oxidative stress in vivo under experimental conditions observed through a fluorescence microscope. Left: green fluorescent protein (GFP) attached to superoxide dismutase 3 enzyme (endogenous antioxidant), allowing for quantitative measurement of oxidative stress with fluorescence intensity; right: GFP attached to DAF-16 transcription factor for qualitative assessment of oxidative stress impact in C. elegans in

Alzheimer's and the Aging Brain

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Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that causes neuronal loss and characterized to have the histopathological hallmarks of β-amyloid plaques and neurofibrillary tangles. The current hypotheses for the etiology and treatment of AD were deduced from these hallmarks, centering on proteopathic cascade hypotheses such as the β-amyloid cascade hypothesis and the phosphorylated-tau hypothesis.

  • Portrait of Auguste Deter, the first patient diagnosed with Alzheimer's Disease.