Neuroscience

Characterized by a gradual disintegration of the neuronal network, neurodegeneration lies at the crossroads of numerous pathologies such as Parkinson’s, Alzheimer’s disorders, multiple sclerosis, stroke, and others. While the cause of neurodegeneration is often multifactorial in nature (e.g., genetic, age, environmental factors), oxidative damage tends to be a common denominator in the process.

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that causes neuronal loss and characterized to have the histopathological hallmarks of β-amyloid plaques and neurofibrillary tangles. The current hypotheses for the etiology and treatment of AD were deduced from these hallmarks, centering on proteopathic cascade hypotheses such as the β-amyloid cascade hypothesis and the phosphorylated-tau hypothesis.